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THE EFFECT OF A 12 WEEKS AER OBIC EXERCISE ON IMMUNOLOGICAL MEASURES OF HIV POSITIVE CLIENTS ON ART.

 

 

The Effect of a 12-Week Aerobic Exercise on Immunological Measures of HIV-Positive Clients on ART

Chapter one

Introduction

Since the identification of Acquired Immune Deficiency Syndrome (AIDS) in humans in 1981, Uganda has undergone noteworthy transformations in the standard of living. Human Immunodeficiency Virus (HIV), the culprit behind AIDS, gradually undermines the immune system, giving rise to various complications. With a population of over 1.5 million individuals grappling with HIV in Uganda, addressing the accompanying challenges is imperative.

In 2020, the United Nations Programme on HIV & AIDS (UNAIDS) underscored the global impact of HIV, underscoring its status as a substantial public health concern. Africa, specifically Uganda, shoulders a significant burden, contributing to about two-thirds of new infections worldwide in 2018.

People living with HIV (PLHIV) in Uganda often confront mental health disorders, exacerbated by the disruption of mental health services due to the COVID-19 pandemic. Furthermore, the side effects of Anti-retroviral Therapy (ART), while enhancing life expectancy, present challenges such as fatigue, nausea, pain, and diminished functional work capacity.

 

The financial strain of HIV treatment is considerable, with estimated monthly costs ranging from 254,000/= to 524,000/= for adults. Many PLHIV also grapple with the hardship of covering long distances for treatment, further elevating the cost of care.

Aerobic exercise is emerging as a promising intervention to mitigate the symptoms, complications, and side effects linked with chronic HIV infection. Research suggests that aerobic exercise can enhance overall health, mood, life satisfaction, and quality of life for PLHIV. Despite these advantages, there is a noticeable lack of emphasis on the integration of aerobic exercise in clinical settings in Uganda.

Aerobic exercise, characterized by low to moderate-intensity physical activity utilizing oxygen in metabolic processes, offers numerous health benefits. These encompass strengthening muscles, improving circulation efficiency, reducing blood pressure, and enhancing overall well-being. Studies indicate improvements in CD4 counts, a crucial immunological marker, with appropriate exercise.

 

The present study aims to bridge the knowledge gap by exploring the implications of a 12-week aerobic exercise program on the clinical outcomes of PLHIV on ART across various regions of Uganda. Focusing on immunological measures, functional work capacity, and psychosocial markers, the study endeavors to provide valuable insights into the potential benefits of aerobic exercise in the Ugandan context. While ART has undeniably enhanced the lives of PLHIV, challenges persist in advanced HIV illnesses, indicating suboptimal clinical outcomes. Adverse alterations linked to ART, compounded by factors like obesity and a sedentary lifestyle, underscore the necessity for adjunct therapies. Aerobic exercise therapy has the potential to augment the quality of life, reduce the overall cost of HIV treatment, and address psychological effects and non-communicable diseases.

 

The Ministry of Health’s guidelines advocate for aerobic exercise as an intervention for PLHIV, but the lack of specific details on the exercises and their benefits presents a challenge. This study endeavors to fill this void by scrutinizing the impact of aerobic exercise on clinical outcomes in Uganda.

The implications of aerobic exercise on the clinical outcomes of HIV-positive clients in Uganda are profound and merit attention. Tackling the challenges faced by PLHIV through interventions like aerobic exercise can contribute to improving the overall health, well-being, and quality of life of individuals living with HIV. This study aspires to offer valuable insights that can shape healthcare practices and policies for enhanced HIV management in Uganda, aligning with the topic.

Literature review

The management of Human Immunodeficiency Virus (HIV) through Antiretroviral Therapy (ART) has improved the quality of life for People Living with HIV (PLHIV). Despite the benefits, ART is associated with potential side effects impacting overall well-being. This article investigates the potential benefits of a 12-week aerobic exercise program on immunological measures in HIV-positive clients on ART.

Antiretroviral Therapy, particularly Highly Active Antiretroviral Therapy (HAART), has improved the quality of life for PLHIV. However, side effects such as fatigue, nausea, and psychological issues affect patients. Aerobic exercises, particularly low-intensity and long-duration ones, have shown positive impacts on physical and mental health, providing an alternative therapy. Research indicates improvements in general health, mood, and life satisfaction among HIV-positive individuals engaging in aerobic exercises.

Studies have observed significant increases in CD4 counts among HIV-positive individuals on ART engaging in regular aerobic exercise, suggesting potential benefits in immunological measures. Despite global research on exercise benefits, there is limited emphasis on aerobic exercises in managing HIV-positive clients in Uganda, emphasizing the need for more studies.

 

Aerobic exercise is consistently listed as one of the most popular self-care therapies for managing HIV and AIDS-related symptoms. Integrating aerobic exercises into the treatment regimen is recommended to extend the asymptomatic phase, reduce drug use, lower healthcare costs, and enhance overall treatment outcomes.

 

The measurement of immune activation and cellular concentration of HIV illness is crucial. Studies show that a 12-week aerobic exercise program can positively impact lipid profiles and CD4 cell counts, indicating improvements in immune function. However, the correlation between viral load, CD4 count, and exercise regimen compliance requires further exploration.

 

Functional work capacity, often estimated through VO2max, is crucial for individuals with HIV infection. Research suggests that aerobic exercise can significantly improve VO2max and functional work capacity in HIV-positive individuals. Utilizing the Duke Activity Status Index (DASI) and Rating of Perceived Exertion (RPE) can provide insights into the effectiveness of exercise interventions on functional capacity.

Psychological markers, including anxiety, depression, and overall mental well-being, play a significant role in the overall health of PLHIV. Various studies indicate that aerobic exercise has antidepressant and anxiolytic properties, positively influencing mental health outcomes. The use of the Borg CR10 scale, DASI, and RPE can help quantify the psychological impact of exercise interventions.

A 12-week aerobic exercise program holds promising potential for positively influencing immunological measures, functional work capacity, and psychological markers in HIV-positive clients on ART. Further research and clinical emphasis on tailored aerobic exercise regimens are essential to optimize the overall health and well-being of individuals living with HIV. As Uganda and other regions continue to address the challenges of HIV/AIDS, incorporating evidence-based exercise interventions into comprehensive care strategies may contribute to improved outcomes for PLHIV.

Living with HIV poses not only physical challenges but also significant psychological burdens for individuals on ART. This article explores the existing literature on the psychological and immunological impacts of aerobic exercise on HIV-positive clients undergoing ART, shedding light on the potential benefits of incorporating structured exercise regimens into their treatment plans.

Research conducted by Seid et al. (2020) revealed a two-fold increased risk of poor treatment outcomes and mortality from AIDS among individuals with chronic depressive symptoms. Depression, anxiety, and neuroticism are prevalent in those living with HIV, often leading to insomnia and further exacerbating their mental health struggles. However, interventions such as stress management, aerobic exercise, and a combination of massage and exercise have shown promise in alleviating psychological symptoms and improving overall mental health.

 

Numerous studies highlight the positive impact of aerobic exercise on psychological markers. Exercise has been shown to reduce symptoms of anxiety and depression, with high-intensity workouts proving more effective in some cases. The combination of exercise and antidepressants has demonstrated improved clinical outcomes, emphasizing the potential of structured exercise programs in enhancing the quality of life for individuals with anxiety disorders.

As HIV infection transitions into a chronic condition due to advances in ART, the importance of managing comorbidities and promoting overall health becomes paramount. Studies emphasize the role of aerobic exercise in slowing disease progression, enhancing immune function, and improving various health indices in HIV-positive clients. Exercise has shown to mitigate side effects of ART, such as inflammation, oxidative stress, and mitochondrial dysfunction. While existing studies provide valuable insights, there is a gap in research specific to Uganda and a lack of clarity on the types and intensity of exercises undertaken by participants. This article underscores the need for tailored exercise programs, specifying intensity, duration, and types of exercises to maximize the benefits for HIV-positive individuals on ART.

The multifaceted impact of aerobic exercise on both psychological well-being and immunological measures in HIV-positive clients on ART is explored. Structured exercise programs have the potential to address not only the psychological challenges associated with living with HIV but also contribute to immune modulation and overall health improvement. Further research, particularly in the context of Uganda, is needed to guide clinicians in designing effective and culturally relevant exercise interventions for this population. As the evidence suggests, integrating aerobic exercise into the comprehensive care of HIV-positive individuals can significantly enhance their quality of life and contribute to long-term well-being.

CHAPTER THREE

Research Design

A quasi-experimental research design was selected for this study.

Location of the Study

The study was conducted at the General Military Hospital (GMH) Bombo in Luwero District, central Uganda.

Target Population

The target demographic comprised HIV-positive patients receiving care at General Military Hospital-Bombo, specifically those on ART for 12 months or more and aged 20 years and above. This group constituted the majority of the 4150 clients receiving ART treatment at GMH.

Inclusion and Exclusion Criteria

Inclusion criteria encompassed clients meeting specific conditions such as being asymptomatic, on ART for 12 months and more, and volunteering for aerobic exercise sessions. Exclusion criteria considered limitations to exercise, opportunistic infections, signs and symptoms of HIV disease, and the age category of children, adolescents, and clients on ART for less than 12 months.

Sampling Procedure and Sample Size

After extensive health education sessions, 135 volunteers meeting the inclusion criteria were enrolled in the study out of the 3300 eligible clients. The sample size determination utilized Yemen’s formula, resulting in a study sample of 99 participants.

Quantitative data were analyzed using two-sample t-tests, with a significance level set at p ≤ 0.05. The Statistical Package for Social Sciences (SPSS) version 20.0 was used for all analyses.

 

 

 

 

 

 

 

 

THE IMPACT OF A 12 WEEKS AEROBIC EXERCISE ON FUNCTIONAL WORK CAPACITY OF HIV POSITIVE CLIENTS ON ART.

 

Background of the study

Since the declaration of Acquired Immune Deficiency Syndrome (AIDS) in 1981, significant advancements have been made in understanding and managing Human Immunodeficiency Virus (HIV). The global prevalence of HIV/AIDS remains a critical public health concern, particularly in sub-Saharan Africa, where a substantial number of individuals are living with the virus. In Uganda, the Ministry of Health acknowledges the high prevalence of mental disorders among People Living with HIV (PLHIV), aggravated by the challenges posed by the COVID-19 pandemic. This article explores the implications of incorporating aerobic exercise into the treatment regimen for HIV-positive clients on Antiretroviral Therapy (ART) in Uganda, focusing on its impact on functional work capacity.

As of 2021, over 1.5 million new HIV infections were reported globally, with Africa being the most affected region. In Uganda, more than 2.5 million people have died due to AIDS, and 1.5 million individuals continue to live with HIV. Mental health issues among PLHIV in Uganda are common but often go unrecognized, a situation further exacerbated by the disruptions caused by the COVID-19 pandemic.

Scientific breakthroughs, particularly in the form of Antiretroviral Therapy (ART), have significantly improved the quality of life and life expectancy of those infected with HIV. However, these treatments come with negative side effects, including exhaustion, nausea, pain, anxiety, and a decrease in functional work capacity. Multi-sectoral approaches are needed to mitigate these side effects and enhance adherence to ART.

Recent studies highlight the potential benefits of aerobic exercise in managing symptoms, complications, and side effects associated with chronic HIV infection. Aerobic exercise is recommended as a means to address various ART side effects, improve mood, enhance life satisfaction, and ultimately boost the quality of life for PLHIV. Studies have shown that exercise therapy should begin soon after an HIV diagnosis to delay the onset and severity of symptoms, potentially slowing disease progression. Despite these recommendations, there is a lack of emphasis on the use of aerobic exercise for PLHIV in Uganda. The article underscores the need for more comprehensive and specific guidelines on the incorporation of exercise into HIV management protocols. It addresses the existing gap in literature by investigating the implications of a 12-week aerobic exercise program on clinical outcomes for HIV-positive clients in various regions of Uganda.

 

As Uganda grapples with the challenges posed by the HIV/AIDS epidemic, this study seeks to contribute valuable insights into the role of aerobic exercise in enhancing clinical outcomes for PLHIV on ART. By understanding the impact on functional work capacity, the study aims to provide a foundation for tailored exercise prescriptions that can be integrated into the existing HIV management guidelines, ultimately improving the quality of life for those living with HIV in Uganda.

LITERATURE

This article explores the impact of a 12-week aerobic exercise regimen on the functional work capacity of HIV-positive clients undergoing Antiretroviral Therapy (ART). The focus is on the human immunodeficiency virus (HIV) and the potential benefits and side effects associated with ART. The article delves into the role of aerobic exercises in enhancing the physical and mental health of HIV-infected clients and their potential to alleviate the side effects of ART. Additionally, the study aims to address the scarcity of information on the utilization of exercise therapy among HIV-positive clients in Uganda.

Introduction:

Antiretroviral Therapy (ART) has become a cornerstone in managing HIV, offering improved quality of life but presenting potential side effects. This article examines the negative impacts of ART, including fatigue, nausea, and reduced functional work capacity, emphasizing the need for alternative therapies such as aerobic exercise.

There are positive effects of aerobic exercise on HIV-positive individuals, drawing on studies that demonstrate improvements in general health, mood, and quality of life. Notably, increased CD4 counts suggest potential benefits for those on ART who engage in regular exercise.

Incorporating aerobic exercises into the management of HIV symptoms, particularly for clients not experiencing severe infections. Customized aerobic exercise regimens involving moderate-intensity activities such as walking, cycling, and rowing are suggested, with progressive resistance training introduced after an initial period of aerobic exercise.

The insights into the recommended exercise intensity levels, with MET levels used to gauge oxygen consumption intensities. Activities like low-intensity jogging, walking, dancing, and cycling are endorsed for HIV-positive individuals to enhance their functional capacity.

There is positive correlation between aerobic exercise and increased CD4 cell counts, highlighting the potential benefits for individuals on ART.

In enhancing the immune system key immunological factors such as viral load and CD4 cell count, emphasizing the importance of exercise in enhancing immune function and reducing the risk of opportunistic infections.

The concept of functional work capacity and its estimation through maximal oxygen consumption or VO2max. Studies are cited, demonstrating the improvement in functional capacity following aerobic exercise in HIV-positive individuals.

This article explains the use of RPE and DASI to measure perceived exertion and functional capacity, respectively. The DASI score is associated with improved functional work capacity, providing valuable insights for clinicians.

This study delves into the psychological benefits of exercise, specifically its positive effects on anxiety, depression, and overall mental well-being in HIV-positive individuals. Various studies are referenced, emphasizing exercise as a supplementary treatment for psychological conditions.

This article further suggests incorporating exercise therapy to address psychological symptoms in HIV-positive individuals, advocating for a holistic approach that combines exercise with other therapeutic interventions.

This comprehensive review underscores the potential of a 12-week aerobic exercise program to positively impact the functional work capacity of HIV-positive clients on ART. The evidence presented supports the integration of tailored aerobic exercises into the management of HIV, emphasizing the need for further research and the development of exercise protocols specific to the Ugandan context. The article calls for increased awareness among clinicians regarding the benefits of exercise in enhancing the overall well-being of HIV-positive individuals.

 

 

 

 

 

 

 

 

THE EFFECTS OF A 12 WEEKS AEROBIC EXERCISE ON ANXIETY AND DEPRESSION OF HIV POSITIVE CLIENTS ON ART

 

 

Background

Since the onset of Acquired Immune Deficiency Syndrome (AIDS) in 1981, triggered by the Human Immunodeficiency Virus (HIV), substantial progress has been made in handling the disease. Antiretroviral Therapy (ART), particularly the Highly Active Antiretroviral Therapy (HAART), has significantly enhanced the well-being and life expectancy of individuals living with HIV. Nevertheless, persistent challenges persist, notably mental health issues such as anxiety and depression among those on ART.

Uganda, akin to numerous African nations, grapples with a substantial HIV burden. According to UNAIDS, Uganda has witnessed over 2.5 million AIDS-related deaths, with more than 1.5 million people currently living with HIV. Mental disorders, often undetected and untreated, are prevalent among people living with HIV (PLHIV), a situation further compounded by disruptions caused by the COVID-19 pandemic. While ART has notably improved the health outcomes of PLHIV, it is not without its drawbacks. Adverse side effects like exhaustion, nausea, pain, anxiety, and sadness are associated with ART. Additionally, the financial strain and the necessity for regular hospital visits pose challenges, particularly for those in remote areas.

Aerobic exercise has emerged as a potential adjunct treatment to alleviate symptoms, complications, and unwanted side effects linked with chronic HIV infection. Research indicates that aerobic exercise can enhance the health, mood, life satisfaction, and overall quality of life for individuals with HIV/AIDS. However, despite these recommendations, the utilization of aerobic exercise in managing HIV in Uganda has not been widely underscored by clinicians. Despite strides in HIV management, there remains no cure, and certain HIV-positive individuals continue to experience suboptimal clinical outcomes. Adverse alterations associated with ART, combined with issues like obesity, nutritional imbalances, and sedentary lifestyles, contribute to challenges in the HIV response. The study aims to investigate whether a 12-week aerobic exercise program can serve as an adjunct therapy to enhance the quality of life for PLHIV, potentially reducing the overall cost of HIV treatment.

As we await the findings of this study, it is imperative for future research to delve into the specific types, frequencies, and approaches of aerobic exercises most effective for PLHIV. Additionally, integrating this knowledge into clinical practice is essential, equipping healthcare professionals with the tools and understanding to prescribe exercise as a potent means of enhancing the clinical outcomes and mental health of HIV-positive clients on ART.

The exploration of aerobic exercise as a complementary treatment for PLHIV in Uganda holds promise in enhancing their overall well-being. By addressing the physical, psychological, and immunological aspects, a holistic approach to HIV management can be achieved, potentially revolutionizing the landscape of HIV care in the country.

Literature review of the study

Human Immunodeficiency Virus (HIV) remains a global health concern, with Antiretroviral Therapy (ART) playing a pivotal role in managing the condition. While ART, such as Highly Active Antiretroviral Therapy (HAART), has proven benefits, including improved quality of life and reduced mortality, it is not without its drawbacks, such as potential negative side effects.

ART, despite its undeniable benefits, comes with a set of side effects, ranging from fatigue and nausea to neuropsychiatric issues like peripheral neuropathy and insomnia. These challenges can impact the overall well-being of People Living with HIV (PLHIV) and may contribute to psychological distress. Recognizing these issues, researchers have turned their attention to the potential benefits of exercise as a complementary therapy for individuals on ART.

Several studies have highlighted the positive impact of aerobic exercises, particularly those of low intensity and long duration, on the physical and mental health of HIV-infected clients. Aerobic exercise has been shown to match the signs and consequences of long-term HIV infection without the side effects associated with ART. In addition, studies examining the effectiveness of aerobic exercise in adults on ART have reported improvements in general health, mood, life satisfaction, and a decrease in anxiety and depression.

The use of aerobic exercises as part of the management of HIV symptoms is highly recommended. Implementing aerobic exercise therapy early in the diagnosis can potentially postpone the onset and severity of symptoms, slow disease progression, and reduce the overall cost of treating HIV-positive patients. Customized aerobic exercise regimens, starting with moderate-intensity exercises like walking, cycling, and rowing, can be beneficial for HIV-positive clients based on their unique symptomology and functional capabilities.

Aerobic exercise has been linked to positive changes in immunological measures, including an increase in CD4 counts, essential for determining immunity in HIV-positive individuals. While some studies have reported no significant changes in viral load or CD4 count after exercise, others have demonstrated improvements in CD4 cell counts, suggesting the potential benefits of exercise on immune function.

Functional work capacity, often measured by VO2max, is crucial for daily activities and overall quality of life. Studies have shown that aerobic exercise can lead to improvements in functional work capacity, with potential benefits for individuals with HIV infection. The use of the Duke Activity Status Index (DASI) and Rating of Perceived Exertion (RPE) as measurement tools further supports the positive impact of exercise on functional work capacity.

Anxiety and depression are prevalent psychological issues among HIV-positive individuals on ART. Exercise, particularly aerobic activities, has demonstrated positive effects on psychological well-being, including reductions in anxiety and depressive symptoms. The combination of exercise and standard care has shown promise in improving mental health outcomes for PLHIV.

The evidence presented in various studies supports the hypothesis that a 12-week aerobic exercise program can have positive effects on anxiety and depression in HIV-positive clients on ART. While acknowledging the challenges and side effects associated with ART, this article emphasizes the potential of exercise as a complementary therapy. However, it is essential for clinicians to consider personalized exercise regimens, taking into account the unique needs and capabilities of each HIV-positive individual.

 

HIV infection, once considered a life-threatening condition, has become a chronic illness with the advent of Highly Active Antiretroviral Therapy (HAART). While HAART has significantly increased the life expectancy of HIV-positive individuals, it is also associated with various comorbidities, disability issues, and a decline in exercise capacity. Exercise has emerged as a crucial management strategy for promoting the rehabilitation and overall health of HIV/AIDS clients.

Research suggests that exercise plays a vital role in mitigating HIV-related side effects and addressing the cardiometabolic and morphological challenges associated with HAART, including inflammation, oxidative stress, and mitochondrial dysfunction. Numerous studies have demonstrated that exercise can slow down the progression of the disease, improve quality of life, enhance aerobic capacity, increase functional ability, and reduce the cardiovascular disease risk in HIV-positive individuals.

Supervision by qualified health professionals, particularly clinical exercise physiologists, is essential during exercise sessions with HIV-positive clients, ensuring their ability to handle the recommended workload. Factors such as the client’s drug regimen, symptoms, functional ability, and disease stage should be considered when designing exercise programs. The gradual progression approach, involving an increase in the frequency and duration of exercise sessions, is recommended until clients can comfortably endure three to five sessions per week.

Aerobic exercise, ranging from moderate intensity to high intensity, is generally considered safe for both symptomatic and asymptomatic HIV/AIDS patients. The American College of Sports Medicine recommends a combination of aerobic exercise (AE) and progressive resistive exercise (CARE) to enhance various health indices more effectively than either strategy alone.

Resistance training, focusing on large muscular groups, is advised after completing four to six weeks of aerobic training to reduce the risk of immunological problems and enhance overall fitness. Caution is advised against using free weights due to the higher risk of injury.

Clients with HIV/AIDS should obtain medical clearance from their doctors before initiating exercise programs. An exercise stress test under physician supervision is also recommended, considering potential limiting factors that may be present. Dehydration and electrolyte abnormalities, common among HIV clients, can lead to muscle cramping and irregular heartbeats, emphasizing the importance of monitoring these conditions during exercise.

As HIV-positive individuals continue to live longer, maintaining their overall health and well-being becomes increasingly important. This article highlights the positive impact of a 12-week aerobic exercise program on anxiety and depression among HIV-positive clients on ART. By incorporating safe and supervised exercise regimens, individuals living with HIV can experience improved physical and mental health, contributing to a better quality of life in the era of advanced medical interventions for HIV/AIDS.

 

THE EFFECTS OF A 12 WEEKS AEROBIC EXERCISE ON PARANOID IDEATION, PHOBIA AND NEUROTICISM OF HIV POSITIVE CLIENTS ON ART

Background

Since the declaration of Acquired Immune Deficiency Syndrome (AIDS) in 1981, HIV has been a significant global health concern, affecting millions worldwide. In Uganda, the impact of HIV is substantial, with over 1.5 million people living with the virus, according to recent UNAIDS reports. Apart from physical health implications, individuals with HIV often face mental health challenges that are exacerbated by factors like treatment toxicity, comorbidities, and the disruptions caused by the COVID-19 pandemic.

Antiretroviral Therapy (ART), including Highly Active Antiretroviral Therapy (HAART), has significantly improved the quality of life and life expectancy of those infected with HIV. However, these treatments come with potential negative side effects, ranging from exhaustion and nausea to anxiety and decreased functional job ability. Despite the benefits, there is still a need for holistic approaches to mitigate these side effects and prevent additional infections, emphasizing the importance of multi-sectoral interventions.

In Uganda, mental health issues in People Living with HIV (PLHIV) often go unrecognized and untreated. The coexistence of psychological disorders, treatment toxicity, and associated comorbidities further complicates the well-being of individuals. The COVID-19 pandemic has exacerbated the situation by disrupting mental health services, making it crucial to explore alternative interventions to improve the mental health of PLHIV.

Aerobic exercise is emerging as a potential strategy to address symptoms, complications, and side effects associated with chronic HIV infection. Studies suggest that aerobic exercise may alleviate ART side effects and improve overall well-being. It is recommended as a valuable component in managing HIV-positive clients, starting as early as possible after diagnosis to delay symptom onset, reduce severity, and possibly slow disease progression.

Despite these recommendations, there is a notable lack of emphasis on aerobic exercise for PLHIV in Uganda. This study aims to fill this knowledge gap by investigating the effects of a 12-week aerobic exercise program on immunological measures, functional work capacity, and psychological markers in HIV-positive clients on ART across various regions of Uganda.

The study focuses on key clinical outcomes, including immunological measures such as CD4 and CD8 T-lymphocytes, total lymphocyte count, and immune activation measures. Functional work capacity, assessed by maximal oxygen consumption (VO2max), reflects a client’s ability to carry out daily tasks without undue fatigue. Psychological markers, including paranoid ideation, phobia, neuroticism, depression, and anxiety, will also be examined as indicators of improvement.

The study recognizes the link between HIV/AIDS patients being overweight/obese with hypercholesteremia and the emergence of Non-Communicable Diseases (NCDs). Targeted weight management programs are identified as crucial elements of HIV therapy, considering factors such as age, sex, disease stage, CD4 levels, and physical activity.

Challenges in the current approach to HIV management include high treatment costs, long travel distances for services, and inadequate exposure of clinicians to exercise physiology and prescription. The study seeks to provide insights into the specific benefits of aerobic exercise and guide clinicians on its application in improving clinical outcomes for PLHIV.

 

 

 

 

Literature review

Living with HIV poses various challenges, not only physically but also psychologically. Antiretroviral Therapy (ART) has significantly improved the quality of life for People Living with HIV (PLHIV), but it comes with potential side effects such as fatigue, depression, and anxiety. While exercise has been recognized for its positive effects on physical health, its impact on psychological markers like paranoid ideation, phobia, and neuroticism in HIV-positive individuals undergoing ART remains an area of exploration. Numerous studies have established a strong connection between regular exercise and improved mental health in various populations. For HIV-positive individuals, managing psychological symptoms becomes crucial in enhancing overall well-being. Exercise has been shown to reduce stress levels, elevate mood through increased serotonin secretion, and decrease cortisol secretion, a hormone associated with stress. Additionally, exercise aids in weight management, which is vital for lowering risk factors for non-communicable diseases.

Paranoid ideation, phobia, and neuroticism are common psychological challenges faced by individuals living with HIV, especially those on ART. Research suggests that aerobic exercise can have a positive impact on these markers. Studies conducted on healthy individuals and those with chronic diseases indicate that exercise can alleviate symptoms of anxiety and depression. Considering the psychological burden often associated with HIV, exploring the effects of aerobic exercise on paranoid ideation, phobia, and neuroticism becomes imperative.

A 12-week aerobic exercise program tailored to the unique needs and capabilities of HIV-positive clients on ART can provide a structured approach to improving psychological well-being. Moderate-intensity aerobic exercises, including walking, cycling, and rowing, have been recommended for their positive impact on overall health without causing undue stress on the body. These exercises, performed three to six times a week, can be a valuable addition to the holistic management of HIV.

Assessing the impact of aerobic exercise on paranoid ideation, phobia, and neuroticism requires a comprehensive evaluation. Validated scales such as the Borg Rating of Perceived Exertion (RPE) can be utilized to measure perceived exertion during exercise, providing insights into the individual’s effort and tolerance levels. Additionally, the Duke Activity Status Index (DASI) and other relevant psychological assessments can help gauge improvements in functional work capacity and overall mental health.

The holistic approach to managing HIV involves not only antiretroviral therapy but also addressing the psychological challenges faced by individuals living with the virus. A 12-week aerobic exercise program tailored to the unique needs of HIV-positive clients on ART holds promise in alleviating paranoid ideation, phobia, and neuroticism. By incorporating exercise into the treatment plan, healthcare providers can contribute to the overall well-being of their patients, fostering a comprehensive and sustainable approach to HIV management. As further research emerges, the integration of exercise as a therapeutic tool in the context of HIV care should be considered a valuable and potentially transformative aspect of treatment.

 

Results

The impact of aerobic exercise on mental health has been a subject of increasing interest, especially in populations facing unique challenges such as HIV-positive individuals on antiretroviral therapy (ART). Descriptive results on the effects of aerobic exercises on depression, indicating a significant improvement in symptoms. At the post-test stage, 86.0% of participants in the experimental group reported not experiencing depression, compared to 27.5% at the pre-test stage. The paired-samples T-test results further confirm the statistical significance (p < 0.001) and reject the null hypothesis that aerobic exercises have no significant effects on depression.

The effects of aerobic exercises on neuroticism, revealing that 80.8% of the experimental group participants reported relief from neuroticism symptoms after engaging in aerobic exercises. The paired-samples T-test results (p < 0.001) reject the null hypothesis, emphasizing the significant reduction of neuroticism in the experimental group compared to the control group.

These results are consistent with studies linking physical activity to reduced neuroticism and improved psychological well-being. The findings highlight the potential of aerobic exercises to alleviate distressing emotions associated with neuroticism.

The effects of aerobic exercises on anxiety, indicating a substantial improvement in the experimental group. The paired-samples T-test results (p < 0.001) reject the null hypothesis, confirming the significant reduction in anxiety levels for HIV-positive clients on ART engaging in aerobic exercises. The variance analysis reveals a 72.4% improvement in the experimental group compared to 16.7% in the control group, emphasizing the specific benefits of aerobic exercises in reducing anxiety symptoms.

Aerobic exercises demonstrate significant positive effects on depression, neuroticism, and anxiety in HIV-positive clients on ART. These findings contribute to the growing body of evidence advocating for holistic approaches to managing mental health in individuals facing chronic health conditions. Aerobic exercises not only provide physical benefits but also play a crucial role in enhancing the overall well-being of HIV-positive individuals on ART. It is essential for healthcare providers and practitioners to consider integrating aerobic exercise programs into the treatment plans for individuals with HIV.

The presented study provides valuable insights into the potential of aerobic exercises as an adjunctive treatment to improve mental health outcomes for HIV-positive clients on ART, paving the way for a more comprehensive and patient-centered approach to care.

Physical activity has long been associated with various health benefits, and recent research has delved into understanding its impact on psychological well-being, especially in specific populations.

The experimental group reported an average pre-test variance of 44.8%, which improved to 87.2% post-test. In contrast, the control group exhibited a variance of 18.2% in the pre-test and 35.9% in the post-test. These findings suggest a more substantial positive impact on the experimental group, emphasizing the potential contribution of aerobic exercises in reducing phobia among HIV positive clients on ART.

To further validate the results, paired-samples T-tests were conducted, comparing pre-phobia and post-phobia scores in both the experimental and control groups. Table 4.35 displays mean values, standard deviations, and standard error means, indicating a significant difference in the experimental group’s post-phobia scores compared to the control group.

Correlation analysis revealed a lack of correlation between pre-test and post-test phobia results in both groups, strengthening the argument that aerobic exercises independently contributed to the observed improvements.

The paired-samples results in Table 4.37 confirmed the statistical significance of the findings. Both the experimental and control groups showed mean differences within their respective 95% confidence intervals, but the p-values indicated statistical significance. The rejection of the null hypothesis suggests that aerobic exercises have a substantial effect on reducing phobia in HIV positive clients on ART.

The results of this study hold significant implications for the mental health management of HIV positive clients on ART. The findings align with previous research, supporting the idea that aerobic exercises can effectively reduce phobia and anxiety. Broman et al. (2004) and Seid et al. (2020) findings are corroborated, emphasizing the broader positive impact of aerobic exercises on mental well-being.

Considering the prevalence of anxiety disorders, including phobia, among HIV positive clients on ART, incorporating aerobic exercises into their treatment plans could be beneficial. The study’s rejection of the null hypotheses underscores the need for a comprehensive approach to mental health, acknowledging the role of physical activity in alleviating symptoms.

The results provide evidence that aerobic exercises significantly contribute to the reduction of phobia, supporting the importance of holistic care for individuals managing both physical and psychological aspects of their health.

 

Recommendations and conclusions

 

Drawing insights from Seid et al.’s (2020) exploration of chronic depression’s health effects on PLHIV, particularly when ART became available, the article highlights the heightened risk of poor treatment outcomes and increased mortality rates in clients with chronic depressive symptoms. The assumption is made that aerobic exercise, proven to improve depression, could potentially reduce mortality rates in HIV positive clients on ART. Inclusion of exercise scientists in the care and management team of HIV positive clients. Academic institutions adding exercise counseling as a course unit to promote exercise adherence.  Promotion of aerobic exercise training by mental health experts to improve mental health in HIV positive clients. Integration and enforcement of exercise regimens into the management plan of PLHIV by health promotion policy makers and healthcare providers.

The recommendations emphasize the need for a holistic approach involving healthcare providers, policymakers, educators, and support from various stakeholders to integrate exercise as a vital component of the care and management of PLHIV.

 

 

 

 

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